Box4Clinical,riskfactorandradiologicpointerstodirecttargeted(secondline)investigation
Clinicalfeatures
Psychosis,movementdisorder,hypoventilation:anti-NMDAR.
Cognitivedysfunction,seizures:anti-VGKC,anti-NMDAR,HSV,HHV6,anti-GAD,anti-Hu,anti-Ma(otherantibody-mediatedseeBox3).
Subacutebehavioural/personalitychange:HSV,anti-NMDAR,anti-VGKC,HIV,Treponemapallidum(syphilis),Whippledisease,trypano-somiasis#,SSPE,anti-GAD,anti-Hu,anti-Ma(otherantibodymediatedseeBox3).
Hydrophobia,hypersalivation,delerium:rabies,ABLV.
Parkinsonianfeatures:flaviviruses(esp.JEV),anti-DR2(basalgangliaencephalitis).
Brainstemdysfunction:enteroviruses(esp.Ev71),flaviviruses(esp.MVEV,JEV,KUNV),Nipah#,Listeriamonocytogenes,Burkholderiapseudomallei,MTB,anti-Hu,anti-Ma(otherparaneoplasticseeBox3).
Associatedlimbweakness(flaccidparalysis)ortremor:enteroviruses(esp.Ev71,poliovirus),flaviviruses.
Rash:enteroviruses,VZV,HHV6,measles,dengue,rickettsiae,Neisseriameningitidis(Meningococcus).
Associatedpneumonia:Mycoplasmapneumoniae,influenza,Nipah#,Hendra,Coxiellaburnetii(Qfever).
Parotitis,testicularpain:mumps.
Cervicallymphadenopathy:EBV,CMV.
SIADH:anti-VGKC,SLEV?.
Chronicsymptoms:HIV,JCV,BKV,trypanosomiasis#,SSPE,T.pallidum(syphilis),Whippledisease.
Cranialnervepalsy:neuroborreliosis?.
Riskfactors
Neonate(4weeks):HSV-2,CMV,toxoplasmosis,T.pallidum(syphilis),L.monocytogenes,enterovirusesparechovirus.
Infant/Child:HSV,VZV,enteroviruses,HHV6/7,M.pneumoniae,EBV,parechovirus,Bartonellasp.,ADEM.
60years:L.monocytogenes,VZV,HSV.
Female:anti-NMDAR.
Immuno北京中科白癜风医院价格北京中科白癜风医院路线
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